منابع مشابه
The nuclear periphery
In recent years, definitions of the nuclear periphery have become increasingly blurred with the realization that nuclear envelope (NE) and nuclear pore complex (NPC) components interact with and influence the behavior of both nuclear and cytoplasmic structures. The Minisymposium on the Nuclear Periphery reflected this evolving outlook by bringing together an eclectic group of researchers workin...
متن کاملRepair at the nuclear periphery
T elomere association with nuclear pores is critical not only for transcriptional silencing but also for effi cient repair of double-stranded breaks in the subtelomeric region of budding yeast chromosomes, according to Therizols et al. (page 189). As in many organisms, yeast telomeres localize to the nuclear periphery. To determine whether nuclear pore proteins are involved in telomere tetherin...
متن کاملThe nuclear envelope and the architecture of the nuclear periphery
By definition, the eukaryotic cell is characterized by a compartmentation structure that divides the intracellular space into two different regions: (a) the nucleus, which contains the genome and the structures involved in transcription and processing of transcription products; and (b) the cytoplasm, which contains the translational apparatus, the cell organelles, the endomembranes, and a varie...
متن کاملRepairing subtelomeric DSBs at the nuclear periphery.
Nuclear organization creates microenvironments favoring distinct nuclear functions. In budding yeast, silent chromatin regions such as telomeres are clustered at the nuclear periphery, creating zones of transcriptional repression. Recently, in the Journal of Cell Biology, Therizols et al. report that "telomere tethering at the nuclear periphery is essential for DNA double strand break repair in...
متن کاملSRC1, central to the nuclear periphery
says, " since its behavior is reminiscent of the MGM lion. " The team's movies of vesicle opening dynamics confi rmed previous results that both the speed of opening and the ultimate size of the pore were calcium dependent, with lower concentrations causing faster and smaller openings. When they treated vesicles with strontium to prevent them from closing, the bright spots remained, rather than...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2012
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e11-12-0969